Patients with high-grade dysplasia (severe or carcinoma-in-situ) generally have a higher chance for malignant transformation than those with lower-grade dysplasias.

It is extremely important that patients with oral epithelial dysplasia be followed by a specialist who is trained to manage these types of lesions. Eliminating high-risk behaviours and promoting protective behaviours (such as a healthy diet) are essential. Surgical removal of a premalignant lesion may or may not be warranted.

Regardless of removal, periodic close follow-up of the patient for any visual changes to the lesion site is critical because lesions can recur and transformation into a malignant lesion is possible at anytime.​